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Instituto de Biologia Unicamp






ABSTRACTA IB (2) - 1999


P110-99 Lymphoid organ alterations enhanced by sub-lethal doses of Coronaviruses in experimental Trypanosoma cruzi infection in mice

Vérinaud L*, Camargo IJB, Vassallo J, Sakurada JK, Rangel HA

The effect of sub-lethal doses of coronaviruses on the course of disease in CBA mice infected with a mildly pathogenic strain of Trypanosoma cruzi was investigated. The levels of parasitemia, mortality rates and the extent of pathological alterations in the lymphoid organs were determined. The results indicate that the pathologic profile of T. cruzi infection can be profoundly altered by subclinical infection with coronaviruses.
Laboratory Animal Science 49: 35-41, 1999. IF= 0.559
* Phone: (19) 788 7911; e-mail:

P111-99 Interferon Beta Modulates Experimental Autoimmune Encephalomyelitis by Altering the Pattern of Cytokine Secretion

Yasuda CL, Al-Sabbagh A, Oliveira EC, Diaz-Bardales BM, Garcia CAA, Santos LMB*

The mechanism of action underlying the beneficial effect of IFN Beta in multiple sclerosis is poorly understood. Since experimental autoimmune encephalomyelitis (EAE) is the experimental model for multiple sclerosis we investigated the effects of recombinant mouse IFN Beta on the severity of EAE induced in SJL mice and on cytokine production by Th1 and Th2 lymphocytes. The results indicated that rmIFN Beta reduced the disease activity with an IP dosage of U/day every day, and successfully treated EAE mice revealed reduced amounts of IFNBeta; no changes in the levels of IL4 were observed, althouth there was a significant increase in IL 10 and TGFBeta production. Beneficial effects on EAE are associated with inhibition of inflammatory cytokines and stimulation of anti-inflammatory cytokines.Immunological Investigation 28:115-126, l999. IF= 0.787
* Phone: (19) 788 7911; e-mail:

P112-99 A comparison of sperm nucleoprotein composition in the genus Physalaemus (Amphibia, Anura)

Amaral MJLV, Recco-Pimentel SM*, Cardoso AJ

The spermatozoa of 8 species from three groups of the Anuran genus Physalaemus were compared using cytochemical assays for DNA-protein complexes. The results indicated intrageneric variation in composition of sperm basic nuclear protein in Leptodactylidae.Cytobios 100: 147-157, 1999.

P113-99 Mecanismos moleculares de patogenicidade em Salmonella

Brocchi M, Sperandio V, Silveira WD*

Série Monografias, Rev. Da Sociedade Brasileira de Genética, 8: 1-35, 1999.
* Phone: (19) 788 7911; e-mail:

P114-99 Mecanismos moleculares de patogenicidade em Shigella

Brocchi M, Sperandio V, Silveira WD*

Série Monografias, Rev. Da Sociedade Brasileira de Genética, 8: 37-61.
* Phone: (19) 788 7911; e-mail:

P115-99 Mecanismos moleculares de patogenicidade em Vibrio cholerae

Sperandio V, Brocchi M, Silveira WD*

Série Monografias, Rev. Da Sociedade Brasileira de Genética, 8: 63-87.
Phone: (19) 788 7911; e-mail:

P116-99 Evaluation of in vitro toxicity of N,N-dimethyl-2-propen-1-amines isomers

Oliveira DA, Fernandes AMAP, De Conti R, Rodriguez JÁ, Haun M, Souza Brito ARM*, De Castro SL, Duran N

The trypanocidal activities of cis-3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(phenyl)-N,N-dimethyl-2-propen-1-amine (Vb) and cis-3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-bromo-phenyl)-N,N-dimethyl-2-propen-1-anine (Vg) appeared 6.3 and 3.5 fold more active than the trans-isomers, respectively. Neutral red uptake (NRU), tetrazolium salt reduction (MTT), DNA content on V79 fibroblast cell culture and acute toxicity von E. coli were measured. The IC50 through DNA contents was lower for the cis-isomers in both series of compounds Vb: 7.8 m M and Vg: 5.2 m M). NRU values for derivative Vb in isomeric mixture shows the same value as the isolated isomers; however, in the case of Vg a more significant toxicity of the cis-isomer was found. MTT values show that Vg is more toxic than Vb. In both cases, the acute toxicity of the trans-isomers was higher than that of the cis-isomers. Pharmazie 54: 847-850, 1999. IF= 0.504

P117-99 Cyanide-Resistant, ATP-Synthesis-Sustained, and Uncoupling-Protein-Sustained Respiration during Pstharvest Ripening of Tomato Fruit

Arruda P*

Plant Physiology, 119: 1323-1330, 1999. IF= 4.311

P118-99 Identification of a DNA-binding factor that recognizes an alfa-coixin promoter and interacts with a coix Opaque-2 like protein

Ottoboni LMM, Pereira GAG*, Leite A, Arruda P*, Vettore AL, Yunes JÁ, Silva MJ

Plant Molecular Biology 39: 95-104, 1999. IF= 2.852

P119-99 Low temperature and aging-promoter expression of PUMP in potato tuber mitochondria

Arruda P*

Febs Letters 457: 103-106, 1999. IF= 3.504


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